職    稱

 教授

科研方向

 生物育種

招生專業(yè)

 植物保護(hù)（植物病理學(xué)）

聯(lián)系方式

  wzhang@sdau.edu.cn

個人簡介

張文正，男，漢族，中共黨員，教授，博士生導(dǎo)師。2008年獲得中國農(nóng)業(yè)大學(xué)生物學(xué)院理學(xué)博士學(xué)位。在學(xué)術(shù)研究方面，以共同第一作者身份在Plant Cell，Plant Physiology，Nucleic Acid Research，Molecular Plant 等期刊發(fā)表文章，累計影響因子達(dá)60+。自2012年起，科研工作重心轉(zhuǎn)向植物基因編輯育種研究。于2016年、2019年先后任職美國基因編輯育種公司Calyxt、 Inari。2019年在美國聯(lián)合創(chuàng)立生物育種公司NeoGreenBio LLC。自2016年起，利用基因編輯育種技術(shù)在油菜、大豆、苜蓿等作物中創(chuàng)建相關(guān)育種平臺，并開發(fā)多個新品種，包括全球首個投入商業(yè)應(yīng)用的基因編輯苜蓿品種。

教學(xué)背景及工作經(jīng)歷

2025 – 至今山東農(nóng)業(yè)大學(xué)植物保護(hù)學(xué)院，教授

2019 – 2025 共同創(chuàng)立NeoGreenBio LLC生物科技有限公司并擔(dān)任公司經(jīng)理

2019 – 2019 Inari公司，資深科學(xué)家、遺傳轉(zhuǎn)化部門總監(jiān)

2016 – 2018 Calyxt公司，品種開發(fā)科學(xué)家、研發(fā)科學(xué)家、項(xiàng)目經(jīng)理

2012 – 2016 The Samuel Roberts Noble Foundation，博士后

2008 – 2016 University of Colorado，博士后

2004 – 2008 中國農(nóng)業(yè)大學(xué)生物學(xué)院植物生理生化國家重點(diǎn)實(shí)驗(yàn)室，博士

研究方向

1.基因編輯育種技術(shù)在作物抗病、抗蟲新品種開發(fā)中的應(yīng)用；

2.重要油料作物（大豆、油菜等）的生物育種；

3.重要牧草作物（苜蓿等）的生物育種。

代表性科研成果

I論文

Li X*, Zhang W*, Xu T, Ramsey J, Zhang L, Hill R, Hansen KC, Hesselberth JR, Zhao R. Comprehensive in vivo RNA-binding site analyses reveal a role of Prp8 in spliceosomal assembly. Nucleic Acids Res. 2013 Apr 1; 41(6):3805-18.

* Both authors contributed equally to the work.

Zhao LN*, Shen LK*, Zhang WZ*, Zhang W*, Wang Y, Wu WH. Ca²⁺-dependent protein kinase11 and 24 modulate the activity of the inward rectifying K⁺ channels in Arabidopsis pollen tubes. Plant Cell., 2013 Feb; 25(2):649-61.

* These authors contributed equally to the work.

Liu WX*, Zhang FC*, Zhang WZ*, Song LF, Wu WH, Chen YF. Arabidopsis Di19 functions as a transcription factor and modulates PR1, PR2 and PR5 expressions in response to drought stress. Mol Plant., 2013 Sep; 6(5):1487-502.

* These authors contributed equally to the work.

Wang Y*, Zhang WZ*, Song LF, Zou JJ, Su Z and Wu WH. Transcriptome analyses show changes in gene expression to accompany pollen germination and tube growth in Arabidopsis. Plant Physiol., 2008 Nov; 148(3):1201-11.

* Both authors contributed equally to the work.

II 專利授權(quán)

WO2020012365A1- CANOLA WITH HIGH OLEIC ACID, 發(fā)明人: Wenzheng Zhang, Feng zhang., International Publication Date: 2020 Jan 16.

其他科研成果

Park JJ, Dempewolf E, Zhang W, Wang ZY. RNA-guided transcriptional activation via CRISPR/dCas9 mimics overexpression phenotypes in Arabidopsis. PLOS One., 2017 Jun 16; 12(6):e0179410.

Chai M, Zhou C, Molina I, Fu C, Nakashima J, Li G, Zhang W, Park J, Tang Y, Jiang Q, Wang ZY. A class II KNOX gene, KNOX4, controls seed physical dormancy. Proc Natl Acad Sci U S A. 2016 Jun 21;113(25):6997-7002.

Zou JJ, Li XD, Ratnasekera D, Wang C, Liu WX, Song LF, Zhang WZ, Wu WH. Arabidopsis CALCIUM-DEPENDENT PROTEIN KINASE8 and CATALASE3 function in abscisic acid-mediated signaling and H2O2 homeostasis in stomatal guard cells under drought stress. Plant Cell., 2015 May; 27(5):1455-60.

Zhang L, Li X, Hill RC, Qiu Y, Zhang W, Hansen KC, Zhao R. Brr2 plays a role in spliceosomal activation in addition to U4/U6 unwinding. Nucleic Acids Res. 2015 Mar 31;43(6):3286-97.

Zhou C, Han L, Fu C, Chai M, Zhang W, Li G, Tang Y, Wang ZY. Identification and characterization of petiolule-like pulvinus mutants with abolished nyctinastic leaf movement in the model legume Medicago truncatula. New Phytol., 2012 Oct; 196(1):92-100.

Zou J, Song L, Zhang W, Wang Y, Ruan S, Wu WH. Comparative proteomic analysis of Arabidopsis mature pollen and germinated pollen. J Integr Plant Biol., 2009 May; 51(5):438-55.

Song LF, Zou JJ, Zhang WZ, Wu WH, Wang Y.Ion transporters involved in pollen germination and pollen tube tip-growth. Plant Signal Behav., 2009 Dec; 4(12):1193-5.

Wang YF, Fan LM, Zhang WZ, Zhang W, Wu WH. Ca²⁺-permeable channels in the plasma membrane of Arabidopsis pollen are regulated by actin microfilaments. Plant Physiol., 2004 Dec; 136(4):3892-904.